Biology

Zhang DM, Navara R, Yin T, Szymanski J, Goldsztejn U, Kenkel C, Lang A, Mpoy C, Lipovsky CE, Qiao Y, Hicks S, Li G, Moore KMS, Bergom C, Rogers BE, Robinson CG, Cuculich PS, Schwarz JK, Rentschler SL. Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis. Nat Commun. 2021 Sep 24;12(1):5558. doi: 10.1038/s41467-021-25730-0. PMID: 34561429.

Gutstein DE, Morley GE, Tamaddon H, Vaidya D, Schneider MD, Chen J, Chien KR, Stuhlmann H, Fishman GI. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res. 2001 Feb 16;88(3):333-9. doi: 10.1161/01.res.88.3.333. PMID: 11179202; PMCID: PMC3630465.

Gros DB, Jongsma HJ. Connexins in mammalian heart function. Bioessays. 1996 Sep;18(9):719-30. doi: 10.1002/bies.950180907. PMID: 8831288.

Cha MJ, Seo JW, Kim HJ, Kim MK, Yoon HS, Jo SW, Oh S, Chang JH. Early Changes in Rat Heart After High-Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation. J Am Heart Assoc. 2021 Mar 16;10(6):e019072. doi: 10.1161/JAHA.120.019072. Epub 2021 Mar 4. PMID: 33660526; PMCID: PMC8174197.

Azzam EI, de Toledo SM, Little JB. Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses. Cancer Res. 2003 Nov 1;63(21):7128-35. PMID: 14612506.

Amino M, Yoshioka K, Tanabe T, Tanaka E, Mori H, Furusawa Y, Zareba W, Yamazaki M, Nakagawa H, Honjo H, Yasui K, Kamiya K, Kodama I. Heavy ion radiation up-regulates Cx43 and ameliorates arrhythmogenic substrates in hearts after myocardial infarction. Cardiovasc Res. 2006 Dec 1;72(3):412-21. doi: 10.1016/j.cardiores.2006.09.010. Epub 2006 Sep 20. PMID: 17054928.

Kiani S, Kutob L, Schneider F, Higgins KA, Lloyd MS. Histopathologic and Ultrastructural Findings in Human Myocardium After Stereotactic Body Radiation Therapy for Recalcitrant Ventricular Tachycardia. Circ Arrhythm Electrophysiol. 2020;13(11):e008753. doi:10.1161/CIRCEP.120.008753

Miszczyk, M., Sajdok, M., Nożyński, J., Cybulska, M., Bednarek, J., Jadczyk, T., Latusek, T., Kurzelowski, R., Dolla, Ł., Wojakowski, W., Dyla, A., Zembala, M., Drzewiecka, A., Kaminiów, K., Kozub, A., Chmielik, E., Grza Dziel, A., Bekman, A., Gołba, K. S., & Blamek, S. (2022). Histopathological Examination of an Explanted Heart in a Long-Term Responder to Cardiac Stereotactic Body Radiotherapy (STereotactic Arrhythmia Radioablation). Frontiers in cardiovascular medicine, 9, 919823. https://doi.org/10.3389/fcvm.2022.919823

Kim JS, Choi SW, Park YG, Kim SJ, Choi CH, Cha MJ, Chang JH. Impact of High-Dose Irradiation on Human iPSC-Derived Cardiomyocytes Using Multi-Electrode Arrays: Implications for the Antiarrhythmic Effects of Cardiac Radioablation. Int J Mol Sci. 2021 Dec 29;23(1):351. doi: 10.3390/ijms23010351. PMID: 35008778; PMCID: PMC8745341.

Kučera, T., Jedličková, K., Šramko, M., Peichl, P., Cvek, J., Knybel, L., Hurník, P., Neuwirth, R., Jiravský, O., Voska, L., & Kautzner, J. (2023). Inflammation and fibrosis characterize different stages of myocardial remodeling in patients after stereotactic body radiotherapy of ventricular myocardium for recurrent ventricular tachycardia. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 62, 107488. https://doi.org/10.1016/j.carpath.2022.107488

Zhang DM, Szymanski J, Bergom C, Cuculich PS, Robinson CG, Schwarz JK, Rentschler SL. Leveraging Radiobiology for Arrhythmia Management: A New Treatment Paradigm? Clin Oncol (R Coll Radiol). 2021 Sep 14:S0936-6555(21)00334-4. doi: 10.1016/j.clon.2021.09.001. Epub ahead of print. PMID: 34535357.

Glover D, Little JB, Lavin MF, Gueven N. Low dose ionizing radiation-induced activation of connexin 43 expression. Int J Radiat Biol. 2003 Dec;79(12):955-64. doi: 10.1080/09553000310001632895. PMID: 14713573.

Michela P, Velia V, Aldo P, Ada P. Role of connexin 43 in cardiovascular diseases. Eur J Pharmacol. 2015;768:71-76. doi:10.1016/j.ejphar.2015.10.030

Amino M, Yoshioka K, Kamada T, Furusawa Y. The Potential Application of Heavy Ion Beams in the Treatment of Arrhythmia: The Role of Radiation-Induced Modulation of Connexin43 and the Sympathetic Nervous System. Int J Part Ther. 2018;5(1):140-150. doi:10.14338/IJPT-18-00022.1

Amino M, Yoshioka K, Fujibayashi D, Hashida T, Furusawa Y, Zareba W, Ikari Y, Tanaka E, Mori H, Inokuchi S, Kodama I, Tanabe T. Year-long upregulation of connexin43 in rabbit hearts by heavy ion irradiation. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1014-21. doi: 10.1152/ajpheart.00160.2009. Epub 2010 Jan 8. PMID: 20061548.