Case Reports

Peichl P, Sramko M, Cvek J, Kautzner J. A case report of successful elimination of recurrent ventricular tachycardia by repeated stereotactic radiotherapy: the importance of accurate target volume delineation. Eur Heart J Case Rep. 2020 Dec 27;5(2):ytaa516. doi: 10.1093/ehjcr/ytaa516. PMID: 33598611; PMCID: PMC7873794.

Donnelly J, Higgins KA, Souza J, Lloyd M. Accessing the inaccessible: Stereotactic radioablation of premature ventricular complexes originating in the right ventricle in a patient with a mechanical tricuspid valve. HeartRhythm Case Rep. 2021 Jan 21;7(4):229-231. doi: 10.1016/j.hrcr.2021.01.008. PMID: 34026502; PMCID: PMC8129049.

Shoji M, Inaba K, Itami J, Hamada M, Okamoto H, Iwasa T, Ushigusa T, Yoshida M, Matsuyama TA, Otsuka T, Kumagai K, Hirao K, Maguire P, Qian P, Gardner E, Zei PC. Advantages and challenges for noninvasive atrial fibrillation ablation. J Interv Card Electrophysiol. 2020 Oct 26. doi: 10.1007/s10840-020-00904-w. Epub ahead of print. PMID: 33106957.

Amino M, Kabuki S, Kunieda E, Yagishita A, Ikari Y, Yoshioka K. Analysis of depolarization abnormality and autonomic nerve function after stereotactic body radiation therapy for ventricular tachycardia in a patient with old myocardial infarction. HeartRhythm Case Rep. 2021 Feb 12;7(5):306-311. doi: 10.1016/j.hrcr.2021.01.023. PMID: 34026521; PMCID: PMC8134781.

Cvek J, Neuwirth R, Knybel L, Molenda L, Otahal B, Pindor J, Murárová M, Kodaj M, Fiala M, Branny M, Feltl D(July 22, 2014) Cardiac Radiosurgery for Malignant Ventricular Tachycardia. Cureus 6(7): e190. doi:10.7759/cureus.190

Lee J, Bates M, Shepherd E, Riley S, Henshaw M, Metherall P, Daniel J, Blower A, Scoones D, Wilkinson M, Richmond N, Robinson C, Cuculich P, Hugo G, Seller N, McStay R, Child N, Thornley A, Kelland N, Atherton P, Peedell C, Hatton M. Cardiac stereotactic ablative radiotherapy for control of refractory ventricular tachycardia: initial UK multicentre experience. Open Heart. 2021 Nov;8(2):e001770. doi: 10.1136/openhrt-2021-001770. PMID: 34815300.

Narducci ML, Cellini F, Placidi L, Boldrini L, Perna F, Bencardino G, Pinnacchio G, Bertolini R, Cannelli G, Frascino V, Tagliaferri L, Chiesa S, Mattiucci GC, Balducci M, Gambacorta MA, Rossi M, Indovina L, Pelargonio G, Valentini V, Crea F. Case Report: A Case Report of Stereotactic Ventricular Arrhythmia Radioablation (STAR) on Large Cardiac Target Volume by Highly Personalized Inter- and Intra-fractional Image Guidance. Front Cardiovasc Med. 2020 Nov 23;7:565471. doi: 10.3389/fcvm.2020.565471. PMID: 33330640; PMCID: PMC7719630.

Perrin, R., Maguire, P., Garonna, A., Weidlich, G., Bulling, S., Fargier-Voiron, M., De Marco, C., Rossi, E., Ciocca, M., Vitolo, V., & Mirandola, A. (2022). Case Report: Treatment Planning Study to Demonstrate Feasibility of Transthoracic Ultrasound Guidance to Facilitate Ventricular Tachycardia Ablation With Protons. Frontiers in cardiovascular medicine, 9, 849247. https://doi.org/10.3389/fcvm.2022.849247

Yugo D, Lo LW, Wu YH, Chung FP, Lin YJ, Chang SL, Hu YF, Chao TF, Liao JN, Chang TY, Lin CY, Tuan TC, Kuo L, Wu CI, Liu CM, Liu SH, Cheng WH, Lugtu IC, Jain A, Chen SA. Case series on stereotactic body radiation therapy in non-ischemic cardiomyopathy patients with recurrent ventricular tachycardia. Pacing Clin Electrophysiol. 2021 Jun;44(6):1085-1093. doi: 10.1111/pace.14254. Epub 2021 May 15. PMID: 33932305.

Lloyd MS, Wight J, Schneider F, Hoskins M, Attia T, Escott C, Lerakis S, Higgins KA. Clinical experience of stereotactic body radiation for refractory ventricular tachycardia in advanced heart failure patients. Heart Rhythm. 2020 Mar;17(3):415-422. doi: 10.1016/j.hrthm.2019.09.028. Epub 2019 Oct 1. PMID: 31585181.

Bhaskaran A, Downar E, Chauhan VS, Lindsay P, Nair K, Ha A, Hope A, Nanthakumar K. Electroanatomical mapping-guided stereotactic radiotherapy for right ventricular tachycardia storm. HeartRhythm Case Rep. 2019 Sep 30;5(12):590-592. doi: 10.1016/j.hrcr.2019.09.007. PMID: 31890583; PMCID: PMC6926178.

Ho LT, Chen JL, Chan HM, Huang YC, Su MY, Kuo SH, Chang YC, Lin JL, Chen WJ, Lee WJ, Lin LY. First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias. Sci Rep. 2021 May 14;11(1):10360. doi: 10.1038/s41598-021-89857-2. PMID: 33990651; PMCID: PMC8121933.

Mayinger M, Kovacs B, Tanadini-Lang S, Ehrbar S, Wilke L, Chamberlain M, Moreira A, Weitkamp N, Brunckhorst C, Duru F, Steffel J, Breitenstein A, Alkadhi H, Garcia Schueler HI, Manka R, Ruschitzka F, Guckenberger M, Saguner AM, Andratschke N. First magnetic resonance imaging-guided cardiac radioablation of sustained ventricular tachycardia. Radiother Oncol. 2020 Nov;152:203-207. doi: 10.1016/j.radonc.2020.01.008. Epub 2020 Feb 14. PMID: 32067819.

Dusi V, Vitolo V, Frigerio L, Totaro R, Valentini A, Barcellini A, Mirandola A, Perego GB, Coccia M, Greco A, Ghio S, Valvo F, De Ferrari GM, Gnecchi M, Oltrona Visconti L, Rordorf R. First-in-man case of non-invasive proton radiotherapy for the treatment of refractory ventricular tachycardia in advanced heart failure. Eur J Heart Fail. 2021 Jan;23(1):195-196. doi: 10.1002/ejhf.2056. Epub 2020 Nov 25. PMID: 33179329.

Lee Y, Yoon HI, Kim JS, Kim AY, Tsevendee S, Uhm JS. Incessant ventricular tachycardia treated with cardiac radioablation in an 11-year-old boy with dilated cardiomyopathy. HeartRhythm Case Rep. 2021 Jan 5;7(3):186-190. doi: 10.1016/j.hrcr.2020.12.009. PMID: 33786318; PMCID: PMC7987900.

Monroy E, Azpiri J, De La Peña C, Cardona C, Hinojosa M, Zamarripa R, Assad J. Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging Post-robotic Radiosurgical Pulmonary Vein Isolation (RRPVI): First Case in the World. Cureus. 2016 Aug 15;8(8):e738. doi: 10.7759/cureus.738. PMID: 27660737; PMCID: PMC5025292.

Gach HM, Green OL, Cuculich PS, Wittland EJ, Marko A, Luchtefeld ME, Entwistle JM, Yang D, Wilber DJ, Mutic S, Robinson CG. Lessons Learned From the First Human Low-Field MRI Guided Radiation Therapy of the Heart in the Presence of an Implantable Cardiac Defibrillator. Pract Radiat Oncol. 2019 Jul-Aug;9(4):274-279. doi: 10.1016/j.prro.2019.02.003. Epub 2019 Feb 18. PMID: 30790716.

Fiorentino A, Di Monaco A, Surgo A, Vitulano N, Gregucci F, Ludovico E, Carbonara R, Quadrini F, Rubini G, Bonaparte I, Grimaldi M. Linac-based STereotactic Arrhythmia Radioablation (STAR) of ventricular tachycardia: Case report and literature review. Clin Case Rep. 2020 Nov 21;9(1):362-366. doi: 10.1002/ccr3.3530. PMID: 33489183; PMCID: PMC7813061.

Chin R, Hayase J, Hu P, Cao M, Deng J, Ajijola O, Do D, Vaseghi M, Buch E, Khakpour H, Fujimura O, Krokhaleva Y, Macias C, Sorg J, Gima J, Pavez G, Boyle NG, Steinberg M, Shivkumar K, Bradfield JS. Non-invasive stereotactic body radiation therapy for refractory ventricular arrhythmias: an institutional experience. J Interv Card Electrophysiol. 2021 Sep;61(3):535-543. doi: 10.1007/s10840-020-00849-0. Epub 2020 Aug 15. PMID: 32803639.

Martí-Almor J, Jiménez-López J, Rodríguez de Dios N, Tizón H, Vallés E, Algara M. Noninvasive ablation of ventricular tachycardia with stereotactic radiotherapy in a patient with arrhythmogenic right ventricular cardiomyopathy. Rev Esp Cardiol (Engl Ed). 2020 Jan;73(1):97-99. English, Spanish. doi: 10.1016/j.rec.2019.06.004. Epub 2019 Jul 30. PMID: 31375392.

Cuculich PS, Schill MR, Kashani R, Mutic S, Lang A, Cooper D, Faddis M, Gleva M, Noheria A, Smith TW, Hallahan D, Rudy Y, Robinson CG. Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia. N Engl J Med. 2017 Dec 14;377(24):2325-2336. doi: 10.1056/NEJMoa1613773. PMID: 29236642; PMCID: PMC5764179.

Bernstein, H. M., Leon, W., Daly, M. E., Park, P., Ghasemiesfe, A., Beri, N., Eng, M., & Srivatsa, U. N. (2022). Noninvasive Stereotactic Radiation for Refractory Ventricular Tachycardia After Failure of Cardiac Sympathetic Denervation. JACC. Case reports, 4(18), 1189–1194. https://doi.org/10.1016/j.jaccas.2022.06.025

Qian PC, Azpiri JR, Assad J, Gonzales Aceves EN, Cardona Ibarra CE, de la Pena C, Hinojosa M, Wong D, Fogarty T, Maguire P, Jack A, Gardner EA, Zei PC. Noninvasive stereotactic radioablation for the treatment of atrial fibrillation: First-in-man experience. J Arrhythm. 2019 Dec 3;36(1):67-74. doi: 10.1002/joa3.12283. PMID: 32071622; PMCID: PMC7011819.

Haskova J, Jedlickova K, Cvek J, Knybel L, Neuwirth R, Kautzner J. Oesophagopericardial fistula as a late complication of stereotactic radiotherapy for recurrent ventricular tachycardia. Europace. 2022 Feb 9:euab326. doi: 10.1093/europace/euab326. Epub ahead of print. PMID: 35138366.

Bode F, Blanck O, Gebhard M, Hunold P, Grossherr M, Brandt S, Vonthein R, Thiele H, Dunst J, Rades D. Pulmonary vein isolation by radiosurgery: implications for non-invasive treatment of atrial fibrillation. Europace. 2015 Dec;17(12):1868-74. doi: 10.1093/europace/euu406. Epub 2015 Mar 3. PMID: 25736725.

Ipsen S, Blanck O, Oborn B, Bode F, Liney G, Hunold P, Rades D, Schweikard A, Keall PJ. Radiotherapy beyond cancer: target localization in real-time MRI and treatment planning for cardiac radiosurgery. Med Phys. 2014 Dec;41(12):120702. doi: 10.1118/1.4901414. PMID: 25471947.

Qian PC, Quadros K, Aguilar M, Mak R, Zei P, Tedrow UB. Recurrent ventricular tachycardia arising at the treatment borderzone after stereotactic radioablation in a patient with ischemic cardiomyopathy. Europace. 2020 Jul 1;22(7):1053. doi: 10.1093/europace/euaa077. PMID: 32447365.

Jumeau R, Ozsahin M, Schwitter J, Vallet V, Duclos F, Zeverino M, Moeckli R, Pruvot E, Bourhis J. Rescue procedure for an electrical storm using robotic non-invasive cardiac radio-ablation. Radiother Oncol. 2018 Aug;128(2):189-191. doi: 10.1016/j.radonc.2018.04.025. Epub 2018 May 9. PMID: 29753550.

Scholz EP, Seidensaal K, Naumann P, André F, Katus HA, Debus J. Risen from the dead: Cardiac stereotactic ablative radiotherapy as last rescue in a patient with refractory ventricular fibrillation storm. HeartRhythm Case Rep. 2019 Mar 21;5(6):329-332. doi: 10.1016/j.hrcr.2019.03.004. PMID: 31285992; PMCID: PMC6587041.

Loo BW Jr, Soltys SG, Wang L, Lo A, Fahimian BP, Iagaru A, Norton L, Shan X, Gardner E, Fogarty T, Maguire P, Al-Ahmad A, Zei P. Stereotactic ablative radiotherapy for the treatment of refractory cardiac ventricular arrhythmia. Circ Arrhythm Electrophysiol. 2015 Jun;8(3):748-50. doi: 10.1161/CIRCEP.115.002765. PMID: 26082532.

Molon, G., Giaj-Levra, N., Costa, A., Bonapace, S., Cuccia, F., Marinelli, A., Trachanas, K., Sicignano, G., & Alongi, F. (2022). Stereotactic ablative radiotherapy in patients with refractory ventricular tachyarrhythmia. European heart journal supplements : journal of the European Society of Cardiology, 24(Suppl C), C248–C253. https://doi.org/10.1093/eurheartj/suac016

Thosani A, Trombetta M, Shaw G, Oh S, Sohn J, Liu E. Stereotactic arrhythmia radioablation for intramural basal septal ventricular tachycardia originating near the His bundle. HeartRhythm Case Rep. 2021 Jan 28;7(4):246-250. doi: 10.1016/j.hrcr.2021.01.012. PMID: 34026506; PMCID: PMC8129041.

Gerard IJ, Bernier M, Hijal T, Kopek N, Pater P, Stosky J, Stroian G, Toscani B, Alfieri J. Stereotactic Arrhythmia Radioablation for Ventricular Tachycardia: Single Center First Experiences. Adv Radiat Oncol. 2021 Apr 20;6(4):100702. doi: 10.1016/j.adro.2021.100702. PMID: 34095614; PMCID: PMC8165547.

Lyle M, Lloyd M, Higgins K, Sridharan L, Bhatt K, Laskar S, Gupta D, Smith A, Vega D, Tamer A, Daneshmand M, Morris A (2020). Stereotactic Body Radiation for Refractory Ventricular Tachycardia in Patients with Left Ventricular Assist Devices. The Journal of Heart and Lung Transplantation, 39(4), S349. https://doi.org/10.1016/j.healun.2020.01.402

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Huang, L. H., Gao, Z. Z., Li, W. Y., Zhang, H. C., Zheng, J. W., & Liu, X. P. (2022). Stereotactic body radiation therapy for refractory premature ventricular contractions that originate from the left ventricular summit: A case report. Pacing and clinical electrophysiology : PACE, 10.1111/pace.14590. Advance online publication. https://doi.org/10.1111/pace.14590

Zeng LJ, Huang LH, Tan H, Zhang HC, Mei J, Shi HF, Jiang CY, Tan C, Zheng JW, Liu XP. Stereotactic body radiation therapy for refractory ventricular tachycardia secondary to cardiac lipoma: A case report. Pacing Clin Electrophysiol. 2019 Sep;42(9):1276-1279. doi: 10.1111/pace.13731. Epub 2019 Jun 4. PMID: 31116434.

Aras, D., Çetin, E. H. Ö., Ozturk, H. F., Ozdemir, E., Kara, M., Ekizler, F. A., Ozeke, O., Ozcan, F., Korkmaz, A., Kervan, U., Turhan, N., Coskun, N., Tezcan, Y., Huang, H., Aksu, T., & Topaloglu, S. (2022). Stereotactic body radioablation therapy as an immediate and early term antiarrhythmic palliative therapeutic choice in patients with refractory ventricular tachycardia. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 1–9. Advance online publication. https://doi.org/10.1007/s10840-022-01352-4

Krug D, Blanck O, Demming T, Dottermusch M, Koch K, Hirt M, Kotzott L, Zaman A, Eidinger L, Siebert FA, Dunst J, Bonnemeier H. Stereotactic body radiotherapy for ventricular tachycardia (cardiac radiosurgery) : First-in-patient treatment in Germany. Strahlenther Onkol. 2020 Jan;196(1):23-30. doi: 10.1007/s00066-019-01530-w. Epub 2019 Oct 31. PMID: 31673718.

Park JS, Choi Y. Stereotactic Cardiac Radiation to Control Ventricular Tachycardia and Fibrillation Storm in a Patient with Apical Hypertrophic Cardiomyopathy at Burnout Stage: Case Report. J Korean Med Sci. 2020 Jul 13;35(27):e200. doi: 10.3346/jkms.2020.35.e200. PMID: 32657082; PMCID: PMC7358068.

Haskova J, Peichl P, Pirk J, Cvek J, Neuwirth R, & Kautzner J. (2019). Stereotactic radiosurgery as a treatment for recurrent ventricular tachycardia associated with cardiac fibroma. HeartRhythm Case Reports, 5(1), 44–47. https://doi.org/10.1016/j.hrcr.2018.10.007

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Neuwirth R, Cvek J, Knybel L, Jiravsky O, Molenda L, Kodaj M, Fiala M, Peichl P, Feltl D, Januška J, Hecko J, Kautzner J. Stereotactic radiosurgery for ablation of ventricular tachycardia. Europace. 2019 Jul 1;21(7):1088-1095. doi: 10.1093/europace/euz133. PMID: 31121018.

Zucchelli G, Parollo M, Di Cori A, Matteucci F, Berruezo A, Bongiorni MG. Stereotactic ventricular tachycardia radioablation aided by CT-channels analysis in a patient with inaccessible transmural substrate. Europace. 2021 Jan 19:euaa425. doi: 10.1093/europace/euaa425. Epub ahead of print. PMID: 33463671.

Qian PC, Quadros K, Aguilar M, Wei C, Boeck M, Bredfeldt J, Cochet H, Blankstein R, Mak R, Sauer WH, Tedrow UB, Zei PC. Substrate Modification Using Stereotactic Radioablation to Treat Refractory Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy. JACC Clin Electrophysiol. 2021 Jul 27:S2405-500X(21)00599-5. doi: 10.1016/j.jacep.2021.06.016. Epub ahead of print. PMID: 34364832.

Nasu, T., Toba, M., Nekomiya, N., Itasaka, R., Mafune, S., Nakata, T., Ikeda, H., & Yokoshiki, H. (2022). Successful Application of Stereotactic Body Radiation Therapy for Ventricular Tachycardia Substrate in a Patient With Nonischemic Cardiomyopathy. The American journal of cardiology, 184, 149–153. https://doi.org/10.1016/j.amjcard.2022.08.017

Aras D, Ozturk HF, Ozdemir E, Kervan U, Kara M, Cay S, Coskun N, Ozcan F, Korkmaz A, Ozeke O, Topaloglu S, Tezcan Y. Use of Stereotactic Radioablation Therapy as a Bailout Therapy for Refractory Ventricular Tachycardia in a Patient with a No-entry Left Ventricle. J Innov Card Rhythm Manag. 2021 Sep 15;12(9):4671-4675. doi: 10.19102/icrm.2021.120902. PMID: 34595050; PMCID: PMC8476093.