Preclinical
Atrioventricular node ablation in Langendorff-perfused porcine hearts using carbon ion particle therapy: methods and an in vivo feasibility investigation for catheter-free ablation of cardiac
Lehmann HI, Richter D, Prokesch H, Graeff C, Prall M, Simoniello P, Fournier C, Bauer J, Kaderka R, Weymann A, Szabó G, Sonnenberg K, Constantinescu AM, Johnson SB, Misiri J, Takami M, Miller RC, Herman MG, Asirvatham SJ, Brons S, Jäkel O, Haberer T, Debus J, Durante M, Bert C, Packer DL. Atrioventricular node ablation in Langendorff-perfused porcine hearts using carbon ion particle therapy: methods and an in vivo feasibility investigation for catheter-free ablation of cardiac arrhythmias. Circ Arrhythm Electrophysiol. 2015 Apr;8(2):429-38. doi: 10.1161/CIRCEP.114.002436. Epub 2015 Jan 21. PMID: 25609687.
Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation
Rapp F, Simoniello P, Wiedemann J, Bahrami K, Grünebaum V, Ktitareva S, Durante M, Lugenbiel P, Thomas D, Lehmann HI, Packer DL, Graeff C, Fournier C. Biological Cardiac Tissue Effects of High-Energy Heavy Ions - Investigation for Myocardial Ablation. Sci Rep. 2019 Mar 21;9(1):5000. doi: 10.1038/s41598-019-41314-x. PMID: 30899027; PMCID: PMC6428839.
Catheter-free ablation of infarct scar through proton beam therapy: Tissue effects in a porcine model
Hohmann S, Deisher AJ, Konishi H, Rettmann ME, Suzuki A, Merrell KW, Kruse JJ, Fitzgerald ST, Newman LK, Parker KD, Monahan KH, Foote RL, Herman MG, Packer DL. Catheter-free ablation of infarct scar through proton beam therapy: Tissue effects in a porcine model. Heart Rhythm. 2020 Dec;17(12):2190-2199. doi: 10.1016/j.hrthm.2020.07.011. Epub 2020 Jul 14. PMID: 32673796.
Catheter-Free Arrhythmia Ablation Using Scanned Proton Beams: Electrophysiologic Outcomes, Biophysics, and Characterization of Lesion Formation in a Porcine
Suzuki A, Deisher AJ, Rettmann ME, Lehmann HI, Hohmann S, Wang S, Konishi H, Kruse JJ, Cusma JT, Newman LK, Parker KD, Monahan KH, Herman MG, Packer DL. Catheter-Free Arrhythmia Ablation Using Scanned Proton Beams: Electrophysiologic Outcomes, Biophysics, and Characterization of Lesion Formation in a Porcine Model. Circ Arrhythm Electrophysiol. 2020 Oct;13(10):e008838. doi: 10.1161/CIRCEP.120.008838. Epub 2020 Sep 13. PMID: 32921132.
Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction
Stein M, van Veen TA, Remme CA, Boulaksil M, Noorman M, van Stuijvenberg L, van der Nagel R, Bezzina CR, Hauer RN, de Bakker JM, van Rijen HV. Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction. Cardiovasc Res. 2009 Jul 1;83(1):52-60. doi: 10.1093/cvr/cvp124. Epub 2009 Apr 22. PMID: 19389723.v
Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43
Gutstein DE, Morley GE, Tamaddon H, Vaidya D, Schneider MD, Chen J, Chien KR, Stuhlmann H, Fishman GI. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res. 2001 Feb 16;88(3):333-9. doi: 10.1161/01.res.88.3.333. PMID: 11179202; PMCID: PMC3630465.
Dose-escalation study for cardiac radiosurgery in a porcine model
Blanck O, Bode F, Gebhard M, Hunold P, Brandt S, Bruder R, Grossherr M, Vonthein R, Rades D, Dunst J. Dose-escalation study for cardiac radiosurgery in a porcine model. Int J Radiat Oncol Biol Phys. 2014 Jul 1;89(3):590-8. doi: 10.1016/j.ijrobp.2014.02.036. Epub 2014 Apr 18. Erratum in: Int J Radiat Oncol Biol Phys. 2014 Dec 1;90(5):1264. PMID: 24751407.
Electrophysiological and Pathological Impact of Medium-Dose External Carbon Ion and Proton Beam Radiation on the Left Ventricle in an Animal Model
Takami, M., Hara, T., Okimoto, T., Suga, M., Fukuzawa, K., Kiuchi, K., Suehiro, H., Akita, T., Takemoto, M., Nakamura, T., Sakai, J., Yatomi, A., Nakasone, K., Sonoda, Y., Yamamoto, K., Takahara, H., & Hirata, K. I. (2021). Electrophysiological and Pathological Impact of Medium-Dose External Carbon Ion and Proton Beam Radiation on the Left Ventricle in an Animal Model. Journal of the American Heart Association, 10(7), e019687. https://doi.org/10.1161/JAHA.120.019687
External Arrhythmia Ablation Using Photon Beams
Lehmann HI, Deisher AJ, Takami M, Kruse JJ, Song L, Anderson SE, Cusma JT, Parker KD, Johnson SB, Asirvatham SJ, Miller RC, Herman MG, Packer DL. External Arrhythmia Ablation Using Photon Beams: Ablation of the Atrioventricular Junction in an Intact Animal Model. Circ Arrhythm Electrophysiol. 2017 Apr;10(4):e004304. doi: 10.1161/CIRCEP.116.004304. PMID: 28408649.
Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams
Lehmann HI, Graeff C, Simoniello P, Constantinescu A, Takami M, Lugenbiel P, Richter D, Eichhorn A, Prall M, Kaderka R, Fiedler F, Helmbrecht S, Fournier C, Erbeldinger N, Rahm AK, Rivinius R, Thomas D, Katus HA, Johnson SB, Parker KD, Debus J, Asirvatham SJ, Bert C, Durante M, Packer DL. Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams. Sci Rep. 2016 Dec 20;6:38895. doi: 10.1038/srep38895. PMID: 27996023; PMCID: PMC5171237.
Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model
Chang JH, Cha MJ, Seo JW, Kim HJ, Park SY, Kim BH, Lee E, Kim MK, Yoon HS, Oh S. Feasibility study on stereotactic radiotherapy for total pulmonary vein isolation in a canine model. Sci Rep. 2021 Jun 11;11(1):12369. doi: 10.1038/s41598-021-91660-y. PMID: 34117284; PMCID: PMC8196028.
In vivo dose measurement using TLDs and MOSFET dosimeters for cardiac radiosurgery
Gardner EA, Sumanaweera TS, Blanck O, Iwamura AK, Steel JP, Dieterich S, Maguire P. In vivo dose measurement using TLDs and MOSFET dosimeters for cardiac radiosurgery. J Appl Clin Med Phys. 2012 May 10;13(3):3745. doi: 10.1120/jacmp.v13i3.3745. PMID: 22584173; PMCID: PMC5716562.
Inducibility of Ventricular Arrhythmia 1 Year Following Treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction
Amino M, Yoshioka K, Furusawa Y, Tanaka S, Kawabe N, Hashida T, Tsukada T, Izumi M, Inokuchi S, Tanabe T, Ikari Y. Inducibility of Ventricular Arrhythmia 1 Year Following Treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction. Pacing Clin Electrophysiol. 2017 Apr;40(4):379-390. doi: 10.1111/pace.13031. Epub 2017 Mar 3. PMID: 28158934.
Left ventricular function after noninvasive cardiac ablation using proton beam therapy in a porcine model
Hohmann S, Deisher AJ, Suzuki A, Konishi H, Rettmann ME, Merrell KW, Kruse JJ, Newman LK, Parker KD, Monahan KH, Foote RL, Herman MG, Packer DL. Left ventricular function after noninvasive cardiac ablation using proton beam therapy in a porcine model. Heart Rhythm. 2019 Nov;16(11):1710-1719. doi: 10.1016/j.hrthm.2019.04.030. Epub 2019 Apr 18. PMID: 31004779.
Noninvasive stereotactic radiosurgery (CyberHeart) for creation of ablation lesions in the atrium.
Sharma A, Wong D, Weidlich G, Fogarty T, Jack A, Sumanaweera T, Maguire P. Noninvasive stereotactic radiosurgery (CyberHeart) for creation of ablation lesions in the atrium. Heart Rhythm. 2010 Jun;7(6):802-10. doi: 10.1016/j.hrthm.2010.02.010. Epub 2010 Feb 13. PMID: 20156591.
Pulmonary vein isolation by radiosurgery: implications for non-invasive treatment of atrial
Bode F, Blanck O, Gebhard M, Hunold P, Grossherr M, Brandt S, Vonthein R, Thiele H, Dunst J, Rades D. Pulmonary vein isolation by radiosurgery: implications for non-invasive treatment of atrial fibrillation. Europace. 2015 Dec;17(12):1868-74. doi: 10.1093/europace/euu406. Epub 2015 Mar 3. PMID: 25736725.
Safety and efficacy of stereotactic radioablation targeting pulmonary vein tissues in an experimental model
Zei PC, Wong D, Gardner E, Fogarty T, Maguire P. Safety and efficacy of stereotactic radioablation targeting pulmonary vein tissues in an experimental model. Heart Rhythm. 2018 Sep;15(9):1420-1427. doi: 10.1016/j.hrthm.2018.04.015. Epub 2018 Apr 18. PMID: 29678783.
Swine Atrioventricular Node Ablation Using Stereotactic Radiosurgery: Methods and In Vivo Feasibility Investigation for Catheter-Free Ablation of Cardiac Arrhythmias
Refaat MM, Ballout JA, Zakka P, Hotait M, Al Feghali KA, Gheida IA, Saade C, Hourani M, Geara F, Tabbal M, Sfeir P, Jalbout W, Al-Jaroudi W, Jurjus A, Youssef B. Swine Atrioventricular Node Ablation Using Stereotactic Radiosurgery: Methods and In Vivo Feasibility Investigation for Catheter-Free Ablation of Cardiac Arrhythmias. J Am Heart Assoc. 2017 Oct 27;6(11):e007193. doi: 10.1161/JAHA.117.007193. PMID: 29079566; PMCID: PMC5721791.
Treatment of arrhythmias by external charged particle beams: a Langendorff feasibility study
Prall M, Lehmann HI, Prokesch H, Richter D, Graeff C, Kaderka R, Sonnenberg K, Hauswald H, Weymann A, Bauer J, Constantinescu A, Haberer T, Debus J, Szabó G, Korkmaz S, Durante M, Packer DL, Bert C. Treatment of arrhythmias by external charged particle beams: a Langendorff feasibility study. Biomed Tech (Berl). 2015 Apr;60(2):147-56. doi: 10.1515/bmt-2014-0101. PMID: 25719279.